Bleomycin A5 hydrochloride is a compound part of the glycopeptide antibiotic family. It is currently used in oncology research for its strong stimulatory and inhibitory effects. Bleomycin A5 greatly reduces telomerase activity, hindering the proliferation of malignant cells. It has also been shown to induce in vivo fibrosis and inflammation by generating peroxynitrites, a strong oxidizing agent.
Bleomycin A5 stimulates downstream apoptosis by increasing cysteine-aspartic acid protease-3 (caspase-3) activity, tumor protein 53 (p53) production and transforming growth factor beta 1 (TGF-beta 1) formation. These proteins induce apoptosis directly or indirectly by halting cell growth.
Product SpecificationsBleomycin A5hydrochloridePingyangmycin1-Bleomycinoic acid hydrochloride
Formula: C57H89N19O21S2
MW: 1477.02 g/mol
Storage/Handling: Store desiccated at 4°C.
PubChem Chemical ID: 84058
