GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

RecombinantRat Chemokine (C-X-C motif) Ligand 10 (CXCL10)CytokineResponsive Gene 2 (CRG2)Small InducibleCytokine Subfamily B Member 10 (SCYB10)InterferonGamma Inducible Protein 10, (IP10, INP10)Mob1, Mob-1

Rat CXCL10 is a CXC chemokine lacking the ELR motif. It is expressed in and secreted by monocytes, endothelial cells, fibroblasts, and other cell types transiently after induction by IFNG or constitutively after induction by oncogenic Ras. It is chemotactic for monocytes and T-cell lymphocytes. CXCL10 plays a role in angiostasis, inhibits bone marrow colony formation, and promotes T-cell adhesion to endothelial cells. Knock-out mice have immune system abnormalities, including defective proliferation of T–cells, resulting in increased susceptibility to autoimmune disease and viral infections. It is closely related to CXCL9 and CXCL11, all three of which are ligands for CXCLR3. Increased expression of CXCL10 and CXCR3 is associated with autoimmune myasthenia gravis.

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~8.7 kDa (77 aminoacids)

Purity: >95% by SDS-PAGEand HPLC analyses

Biological Activity: Fully biologicallyactive when compared to standard. The biological activity determined by a chemotaxisbioassay using human CXCR3 transfected HEK293 cells is in a concentrationrange of 10-50 ng/ml.

Storage/Handling: Store desiccated at-20°C.

RGD: 620209

NOT FOR HUMAN USE!

Additional resources for this protein may be found at:OMIM