Known in its anhydrous form as Coenzyme II, this substance is a fundamental metabolite studied in nucleotide chemistry. Nicotinamide dinucleotide phosphate (NADP) is a coenzyme carrying electrons and hydrogen in a multitude of reactions. Forms include oxidized NADP+ and reduced NADPH, a product of the pentose phosphate pathway (PPP). The molecule acts as an electron acceptor and the conjugate acid to NADP zwitterion.

NADP functions in electron transfer in the anabolic biosynthesis of lipids, cholesterol and fatty acyl chains. The substance can therefore be applied to antioxidant roles preventing oxidative damage. NADP+ and NADPH, paired together for redox reactions, participate in enzyme oxidation-reduction catalysis. NADP is further implicated in metabolism, mitochondrial conditions and apoptosis-induction.

Ferredoxin-NADP+ reductase produces NADPH in photosynthesis and is the reducing agent in the Calvin cycle, transforming CO₂ into glucose for energy. NADP further reduces nitrate in the nitrogen cycle, providing the plant with ammonia. In animals, it contributes to the creation of NADPH and ADP. Reduction powers of NADPH protect these organisms from reactive oxygen species (ROS).

Product SpecificationsCoenzyme IIb-NADPNAPD+beta-Nicotinamide adenine dinucleotide phosphate hydrateNicotinamide adenine dinucleotide phosphateTriphosphopyridine nucleotide

Formula: C₂₁H₂₈N₇O₁₇P₃(anhydrous)

MW: 743.40 g/mol (anhydrous)

Storage/Handling: Store desiccated at 4°C. Protect from light and air.

PubChem Chemical ID: 5885