This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

Product NameBRCA1 Polyclonal AntibodyBRCA1 Rabbit pAbBRCA1; BRCAI; BRCC1;BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53

Host Species Rabbit

Purification Method Affinity purification

IsotypeIgG

Storage/HandlingStore at -20℃.Avoid freeze / thaw cycles.

Storage BufferPBS with 0.02% sodium azide, 50%glycerol, pH7.3.

Immunogen Information

ImmunogenA synthetic peptide corresponding to a sequence within amino acids 120-220 of human BRCA1 (NP_009225.1).

Sequence DEVSIIQSMG YRNRAKRLLQ SEPENPSLQE TSLSVQLSNL GTVRTLRTKQ RIQPQKTSVY IELGSDSSED TVNKATYCSV GDQELLQITP QGTRDEISLD S

Gene ID: 672

Swiss Protein: P38398

Calculated MW: 7 kDa/78-85 kDa/202-210 kDa