The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.

Product NameAndrogen Receptor Polyclonal AntibodyAndrogen Receptor RabbitmAbAIS; AR8; DHTR; HUMARA;HYSP1; KD; NR3C4; SBMA; SMAX1; TFM; AR

Host Species Rabbit

Purification Method Affinity purification

IsotypeIgG

Storage/HandlingStore at -20℃.Avoid freeze / thaw cycles.

Storage BufferPBS with 0.02% sodium azide, 50%glycerol, pH7.3.

Immunogen Information

ImmunogenA synthetic peptide corresponding to a sequence within amino acids 1-100 of human Androgen Receptor (NP_000035.2).

Sequence MEVQLGLGRV YPRPPSKTYR GAFQNLFQSV REVIQNPGPR HPEAASAAPP GASLLLLQQQ QQQQQQQQQQ QQQQQQQQQQ ETSPRQQQQQ QGEDGSPQAH

Gene ID: 367

Swiss Protein: P10275

Calculated MW: 44 kDa/67 kDa/99 kDa

Observed MW: 110 kDa