This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia.
Product NameADA Polyclonal AntibodyADA Rabbit pAbADA
Host SpeciesRabbit
Purification MethodAffinity purification
IsotypeIgG
Storage/HandlingStore at -20℃. Avoid freeze / thaw cycles.
Storage BufferPBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Immunogen Information
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 1-363 of human ADA (NP_000013.2).
SequenceMAQTPAFDKP KVELHVHLDG SIKPETILYY GRRRGIALPA NTAEGLLNVI GMDKPLTLPD FLAKFDYYMP AIAGCREAIK RIAYEFVEMK AKEGVVYVEV RYSPHLLANS KVEPIPWNQA EGDLTPDEVV ALVGQGLQEG ERDFGVKARS ILCCMRHQPN WSPKVVELCK KYQQQTVVAI DLAGDETIPG SSLLPGHVQA YQEAVKSGIH RTVHAGEVGS AEVVKEAVDI LKTERLGHGY HTLEDQALYN RLRQENMHFE ICPWSSYLTG AWKPDTEHAV IRLKNDQANY SLNTDDPLIF KSTLDTDYQM TKRDMGFTEE EFKRLNINAA KSSFLPEDEK RELLDLLYKA YGMPPSASAG QNL
Gene ID: 100
Swiss Protein: P00813
Calculated MW: 40 kDa
Observed MW: 41 kDa
