GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!
RecombinantHuman Thymic Stromal LymphopoietinTSLP
Thymic stromal lymphopoietin (TSLP) is a hemopoietic protein belonging to the cytokine family and is known to play an important role in the maturation of T cell populations through activation of antigen presenting cells. It is mainly expressed in tissues, including heart, liver and prostate. TSLP signals through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL7R alpha chain. Like IL7, TSLP induces phosphorylation of STAT3 and STAT5, but uses kinases other than the JAKs for activation. After binding STAT5, phosphorylation is induced which results in the expression of downstream transcription factors. TSLP enhances the maturation of CD11c+ dendritic cells and induces allergic inflammation by directly activating mast cells. TSLP’s expression is linked to many disease states including asthma, inflammatory arthritis, atopic dermatitis, and eczema and other allergic states but the factors which induce the activation of TSLP release are not clearly defined. Human TSLP shares approximately 43 % amino acid sequence identity with mouse TSLP.
Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.
Source:Escherichia coli
MW:~15.1 kDa (132amino acids)
Purity:>98% by SDS-PAGEand HPLC analyses.
Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human IL-7Rα and human TSLP R co-transfected murine BaF3 pro-B cells is less than 0.3 ng/ml, corresponding to a specific activity of >3.3×106 IU/mg.
Storage/Handling:Store desiccated at-20°C.
HGNC:30743
NOT FOR HUMAN USE!
Additional resources for this protein may be found at:OMIM
