Octylglucoside is a nonionic, mild detergent used to isolate membrane proteins in the native state. It can easily be removed during final extractions by dialysis.

Characteristics that contribute to this detergent’s usefulness are its water solubility, chemical structure and small-sized micelles.

Octylglucoside also provides higher resolution of proteins in 2D electrophoresis.

Product SpecificationsOctylglucoside ultra puren-Octyl-β-D- glucopyranoside n-Octyl-beta-D-Glc

MOLECULAR BIOLOGY GRADE

Formula: C₁₄H₂₈O₆

MW: 292.38 g/mol

Storage/Handling: Store at -15°C, and keep container tightly sealed and dry. This product is very hygroscopic.

PubChem Chemical ID: 62852

Literature:

1. Gould, R. J., Ginsberg, B. H., &Spector, A. A. (1981). Effects of octyl. beta.-glucoside on insulinbinding to solubilized membrane receptors. Biochemistry, 20(24), 6776-6781.
2. Aveldaño, M. I., Diaz, R. S., Regueiro, P., & Monreal, J. (1991). Solubilization of myelin membranes by detergents. Journal of neurochemistry, 57(1), 250-257.
3. Halldén, G., Andersson, U., Hed, J.,& Johansson, S. G. O. (1989). A new membrane permeabilization methodfor the detection of intracellular antigens by flow cytometry. Journal of immunological methods, 124(1), 103-109.
4. Lopez, M. F. (1999). Proteome analysis: I. Gene products are where the biological action is. Journal of Chromatography B: Biomedical Sciences and Applications, 722(1-2), 191-202.
5. Jackson, M. L., Schmidt, C. F.,Lichtenberg, D., Litman, B. J., & Albert, A. D. (1982).Solubilization of phosphatidylcholine bilayers by octyl glucoside. Biochemistry, 21(19), 4576-4582.
6. Mimms, L. T., Zampighi, G., Nozaki,Y., Tanford, C., & Reynolds, J. A. (1981). Phospholipid vesicleformation and transmembrane protein incorporation using octyl glucoside.Biochemistry, 20(4), 833-840.
7. Yoshida, M., Suzuki, A., Yamamoto, H.,Noguchi, S., Mizuno, Y., & Ozawa, E. (1994). Dissociation of thecomplex of dystrophin and its associated proteins into several uniquegroups by n‐octyl β‐D‐glucoside. European journal of biochemistry, 222(3), 1055-1061.